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Thromb Haemost 1996; 75(01): 083-086
DOI: 10.1055/s-0038-1650225
Original Article
Schattauer GmbH Stuttgart

Fat Emulsion Infusion Potentiates Coagulation Activation during Human Endotoxemia

Tom van der Poll
The Cornell University Medical College, Laboratory of Surgical Metabolism, New York, USA; Academic Medical Center, University of Amsterdam, Department of Internal Medicine and Center of Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, Amsterdam, The Netherlands; Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Department of Autoimmune Diseases and Inflammation, Amsterdam, The Netherlands
,
Susette M Coyle
The Cornell University Medical College, Laboratory of Surgical Metabolism, New York, USA; Academic Medical Center, University of Amsterdam, Department of Internal Medicine and Center of Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, Amsterdam, The Netherlands; Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Department of Autoimmune Diseases and Inflammation, Amsterdam, The Netherlands
,
Marcel Levi
The Cornell University Medical College, Laboratory of Surgical Metabolism, New York, USA; Academic Medical Center, University of Amsterdam, Department of Internal Medicine and Center of Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, Amsterdam, The Netherlands; Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Department of Autoimmune Diseases and Inflammation, Amsterdam, The Netherlands
,
Marja A Boermeester
The Cornell University Medical College, Laboratory of Surgical Metabolism, New York, USA; Academic Medical Center, University of Amsterdam, Department of Internal Medicine and Center of Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, Amsterdam, The Netherlands; Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Department of Autoimmune Diseases and Inflammation, Amsterdam, The Netherlands
,
Carla C Braxton
The Cornell University Medical College, Laboratory of Surgical Metabolism, New York, USA; Academic Medical Center, University of Amsterdam, Department of Internal Medicine and Center of Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, Amsterdam, The Netherlands; Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Department of Autoimmune Diseases and Inflammation, Amsterdam, The Netherlands
,
Patty M Jansen
The Cornell University Medical College, Laboratory of Surgical Metabolism, New York, USA; Academic Medical Center, University of Amsterdam, Department of Internal Medicine and Center of Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, Amsterdam, The Netherlands; Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Department of Autoimmune Diseases and Inflammation, Amsterdam, The Netherlands
,
C Erik Hack
The Cornell University Medical College, Laboratory of Surgical Metabolism, New York, USA; Academic Medical Center, University of Amsterdam, Department of Internal Medicine and Center of Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, Amsterdam, The Netherlands; Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Department of Autoimmune Diseases and Inflammation, Amsterdam, The Netherlands
,
Stephen F Lowry
The Cornell University Medical College, Laboratory of Surgical Metabolism, New York, USA; Academic Medical Center, University of Amsterdam, Department of Internal Medicine and Center of Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, Amsterdam, The Netherlands; Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Department of Autoimmune Diseases and Inflammation, Amsterdam, The Netherlands
› Author Affiliations
Further Information

Publication History

Received 24 April 1995

Accepted after resubmission 10 October 1995

Publication Date:
27 July 2018 (online)

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Summary

Intravenous fat emulsions are frequently given to malnourished patients who are prone to suffer from infectious complications. As injection of low dose endotoxin represents a model to study the human response to acute infection, we sought to determine the effect of lipid emulsion infusion on endotoxin-induced activation of the hemostatic mechanism in man. Ten healthy men received a bolus intravenous injection of endotoxin (lot EC-5; 20 U/kg) midway through a 4-h infusion (125 ml/h) of either dextrose 5% (n = 5) or Intralipid 20% (n = 5). Lipid infusion potentiated endotoxin-induced coagulation activation, as indicated by higher plasma levels of the prothrombin fragment FI + 2 and of thrombin-antithrombin III complexes (both p <0.05 for the difference between groups). However, lipid infusion did not influence the fibrinolytic response to intravenous endotoxin, as reflected by similar increases in the levels of tissue-type plasminogen activator and plas-min-α2-antiplasmin complexes in both groups. Endotoxin-induced appearance of plasminogen activator inhibitor type I was enhanced by lipid infusion (p <0.05). These data suggest that fat emulsion infusion may enhance the tendency towards thrombotic complications in patients with infections.